Distinguishing aggregate formation and aggregate clearance using cell based assays
نویسندگان
چکیده
منابع مشابه
Distinguishing aggregate formation and aggregate clearance using cell-based assays.
The accumulation of ubiquitylated proteinaceous inclusions represents a complex process, reflecting the disequilibrium between aggregate formation and aggregate clearance. Although decreasing aggregate formation or augmenting aggregate clearance will ultimately lead to a diminished aggregate burden, in terms of disease pathogenesis, the different approaches can have distinct outcomes. Using a n...
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Laboratory of Veterinary Pharmacology, Laboratory of Protein Sciences, Graduate School of Science, Graduate School of Life and Environmental Sciences, Department of Science, Osaka Prefecture University, Izumisano 5988531, Osaka, Japan Phone: +81-72-463-5274, Fax: +81-72463-5264, Development Research Laboratories, Ono Pharmaceutical Co., Ltd., Mishima-gun 6188585, Osaka, Japan, Phone: +81-75-961...
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ژورنال
عنوان ژورنال: Journal of Cell Science
سال: 2016
ISSN: 1477-9137,0021-9533
DOI: 10.1242/jcs.179978